SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485

Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 (SIRT1) and AMP‐activated protein kinase (AMPK) were previously reported to modulate vascular senescence; however, its effects h...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Jin Young Sung, Seul Gi Kim, Du Hyong Cho, Jae‐Ryong Kim, Hyoung Chul Choi
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2020-07-01
Sarja:	FEBS Open Bio
Aiheet:	p‐AMPK (Ser485) SIRT1 SRT1720 telomere length VSMC senescence
Linkit:	https://doi.org/10.1002/2211-5463.12895
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