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Transcriptional Profiling Reveals Lineage-Specific Characteristics in ATR/CHK1 Inhibitor-Resistant Endometrial Cancer

Recurrent endometrial cancer (EC) has limited therapeutic options beyond platinum-based chemotherapy, highlighting the need to identify exploitable molecular vulnerabilities. Tumors with high genomic instability, including microsatellite instability-high (MSI-h) or copy-number-high (CNH) ECs, rely o...

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Principais autores: Tzu-Ting Huang, Jung-Min Lee
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-01-01
Serier:Biomolecules
Fag:
endometrial cancer
ATR
CHK1
drug resistance
Online adgang:https://www.mdpi.com/2218-273X/16/1/169
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