Individual HLA heterogeneity and its implications for cellular immune evasion in cancer and beyond

Structural and functional variability of human leukocyte antigen (HLA) is the foundation for competent adaptive immune responses against pathogen and tumor antigens as it assures the breadth of the presented immune-peptidome, theoretically sustaining an efficient and diverse T cell response. This va...

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Auteurs principaux:	Simona Pagliuca, Carmelo Gurnari, Marie Thérèse Rubio, Valeria Visconte, Tobias L. Lenz
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2022-09-01
Collection:	Frontiers in Immunology
Sujets:	HLA immunopeptidome HLA evolutionary divergence tumor surveillance immune escape
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.944872/full
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