MicroRNA-10a/b inhibit TGF-β/Smad-induced renal fibrosis by targeting TGF-β receptor 1 in diabetic kidney disease

TGF-β/Smad signaling plays a vital role in the development of fibrosis in diabetic kidney disease (DKD). However, remedies targeting key elements in TGF-β/Smad signaling are lacking. Here, we found that TGF-β receptor 1 (TGFBR1), a key protein in TGF-β/Smad signaling, was upregulated in kidney from...

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Principais autores:	Jinxiang Li, Shuling Yue, Jingwen Fang, Junling Zeng, Siqi Chen, Jianwei Tian, Sheng Nie, Xiaoting Liu, Hanying Ding
格式:	Artigo
語言:	Inglês
出版:	Elsevier 2022-06-01
叢編:	Molecular Therapy: Nucleic Acids
主題:	MT: Non-coding RNAs diabetic kidney disease TGF-β/Smad signaling TGF-β receptor 1 renal fibrosis MicroRNA-10a/b
在線閱讀:	http://www.sciencedirect.com/science/article/pii/S2162253122000786
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