Determination of Genotoxic Impurity <i>N</i>-Nitroso-<i>N</i>-methyl-4-aminobutyric Acid in Four Sartan Substances through Using Liquid Chromatography–Tandem Mass Spectrometry

<i>N</i>-nitroso-<i>N</i>-methyl-4-aminobutyric acid (NMBA) is the third N-nitrosamine impurity found in sartans. Herein, a sensitive and stable LC-MS/MS method with multiple reactions monitoring mode has been developed for the quantitative determination of NMBA in four sartan substances. The effect...

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Principais autores:	Bin Xie, Dong Guo, Binliang Mai, Jun Fan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-11-01
coleção:	Molecules
Assuntos:	N-nitrosamine genotoxic impurity sartan substance <i>N</i>-nitroso-<i>N</i>-methyl-4-aminobutyric acid LC-MS/MS quantitative determination multiple reactions monitoring
Acesso em linha:	https://www.mdpi.com/1420-3049/27/21/7498
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