SPATA2 restricts OTULIN-dependent LUBAC activity independently of CYLD

Summary: SPATA2 mediates the recruitment of CYLD to immune receptor complexes by bridging the interaction of CYLD with the linear ubiquitylation assembly complex (LUBAC) component HOIP. Whether SPATA2 exhibits functions independently of CYLD is unclear. Here, we show that, while Cyld−/− and Spata2−/...

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Autors principals:	Laura Griewahn, Madeleine Müller, Lukas Peintner, Manuela Wissler, Martina Weiss, Prisca Brauns-Schubert, Ramin Massoumi, Christoph Borner, Olaf Groß, Monica Yabal, Céline Charvet, Ulrich Maurer
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-01-01
Col·lecció:	Cell Reports
Matèries:	CP: Molecular biology CP: Immunology
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124722018654
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