Structural interactions of BWC0977 with Klebsiella pneumoniae topoisomerase IV and biochemical basis of its broad-spectrum activity

Abstract Antimicrobial resistance is a growing global health crisis driving the urgent need for effective broad-spectrum antibiotics. BWC0977 is a pyrazino-oxazinone based novel bacterial topoisomerase inhibitor (NBTI) currently in Phase 1 clinical trials and demonstrates potent activity against mul...

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Principais autores:	Radha Nandishaiah, Satoshi Murakami, Shahul Hameed P, Maho Aoki, Ui Okada, Eiki Yamashita, Suryanarayanan Venkatesan, Nagakumar Bharatham, Sudipta Sarma, Anirudh P. Shanbhag, Sreevalli Sharma, Ranga Rao, Vasanthi Ramachandran, V. Balasubramanian, Santanu Datta, Nainesh Katagihallimath
格式:	Artigo
语言:	Inglês
出版:	Nature Portfolio 2025-11-01
丛编:	Communications Biology
在线阅读:	https://doi.org/10.1038/s42003-025-09055-y
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