Increased human Ca²⁺-activated Cl^- channel 1 expression and mucus overproduction in airway epithelia of smokers and chronic obstructive pulmonary disease patients

<p>Abstract</p> <p>Background</p> <p>The mechanisms underlying the association between smoking and mucus overproduction remain unknown. Because of its involvement in other airway diseases, such as asthma, we hypothesized that Ca²⁺-activated Cl^- channel 1 (CLCA1) was associated...

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Detalhes bibliográficos

Principais autores:	Iwashita Hiroki, Fujimoto Keisaku, Morita Shigeru, Nakanishi Atsushi, Kubo Keishi
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2012-06-01
coleção:	Respiratory Research
Assuntos:	Ca<sup>2+</sup>-activated Cl<sup>-</sup> channel 1 (CLCA1) Chronic obstructive pulmonary disease (COPD) Smoking Mucus production Airway epithelia
Acesso em linha:	http://respiratory-research.com/content/13/1/55
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