Apolipoprotein E knockout, but not cholesteryl ester transfer protein (CETP)-associated high-density lipoprotein cholesterol (HDL-C) lowering, exacerbates muscle wasting in dysferlin-null mice

Abstract Background Dysferlin-deficient limb-girdle muscular dystrophy type 2B (Dysf) mice are notorious for their mild phenotype. Raising plasma total cholesterol (CHOL) via apolipoprotein E (ApoE) knockout (KO) drastically exacerbates muscle wasting in Dysf mice. However, dysferlinopathic patients...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Zeren Sun, Zoe White, Marine Theret, Pascal Bernatchez
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-08-01
Schriftenreihe:	Lipids in Health and Disease
Schlagworte:	Muscular dystrophy CETP Dysferlin HDL-C Cholesterol
Online-Zugang:	https://doi.org/10.1186/s12944-024-02227-5
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!