Sonic Hedgehog Signaling in Cranial Neural Crest Cells Regulates Microvascular Morphogenesis in Facial Development

Sonic hedgehog (Shh) pathway disruption causes craniofacial malformations including orofacial clefts (OFCs) of the lip and palate. In normal craniofacial morphogenesis, Shh signals to multipotent cranial neural crest cells (cNCCs) and was recently discovered to regulate the angiogenic transcriptome,...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Miranda R. Sun, Hannah M. Chung, Veronika Matsuk, Dustin M. Fink, Matthew J. Stebbins, Sean P. Palecek, Eric V. Shusta, Robert J. Lipinski
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2020-10-01
Schriftenreihe:	Frontiers in Cell and Developmental Biology
Schlagworte:	perivascular pericyte cranial neural crest Sonic hedgehog orofacial clefting microvascular morphogenesis
Online-Zugang:	https://www.frontiersin.org/article/10.3389/fcell.2020.590539/full
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