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Genome-wide pan-GPCR cell libraries accelerate drug discovery

G protein-coupled receptors (GPCRs) are pivotal in mediating diverse physiological and pathological processes, rendering them promising targets for drug discovery. GPCRs account for about 40% of FDA-approved drugs, representing the most successful drug targets. However, only approximately 15% of the...

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Main Authors: Hanting Yang, Yongfu Wang, Wei Liu, Taiping He, Jiayu Liao, Zhongzhi Qian, Jinghao Zhao, Zhaotong Cong, Dan Sun, Zhixiang Liu, Can Wang, Lingping Zhu, Shilin Chen
Format: Artigo
Language:Inglês
Published: Elsevier 2024-10-01
Series:Acta Pharmaceutica Sinica B
Subjects:
G-protein coupled receptors
Genome-wide pan-GPCR
Transgenic cell library
High-throughput screening
Drug discovery
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383524002545
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