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Determination of ultra-trace metal-protein interactions in co-formulated monoclonal antibody drug product by SEC-ICP-MS

Transition metals can be introduced in therapeutic protein drugs at various steps of the manufacturing process (e.g. manufacturing raw materials, formulation, storage), and can cause a variety of modifications on the protein. These modifications can potentially influence the efficacy, safety, and st...

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Principais autores: Laurence Whitty-Léveillé, Zachary L. VanAernum, Jorge Alexander Pavon, Christa Murphy, Katie Neal, William Forest, Xinliu Gao, Wendy Zhong, Douglas D. Richardson, Hillary A. Schuessler
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis Group 2023-12-01
Serier:mAbs
Fag:
Co-formulation
drug formulation
mAbs
SEC-ICP-MS
ultra-trace metal analysis
Online adgang:https://www.tandfonline.com/doi/10.1080/19420862.2023.2199466
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