Hyperglycemia exacerbates dengue virus infection by facilitating poly(A)-binding protein–mediated viral translation

Diabetes mellitus (DM) is highly comorbid with severe dengue diseases; however, the underlying mechanisms are unclear. Patients with DM have a 1.61-fold increased risk of developing dengue hemorrhagic fever. In search of host factors involved in dengue virus (DENV) infection, we used high-glucose (H...

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Hauptverfasser:	Ting-Jing Shen, Chia-Ling Chen, Tsung-Ting Tsai, Ming-Kai Jhan, Chyi-Huey Bai, Yu-Chun Yen, Ching-Wen Tsai, Po-Chun Tseng, Chia-Yi Yu, Chiou-Feng Lin
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical investigation 2023-01-01
Schriftenreihe:	JCI Insight
Schlagworte:	Infectious disease Virology
Online-Zugang:	https://doi.org/10.1172/jci.insight.142805
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