Integrated multi-omics identifies CRP as a prognostic biomarker and reveals complement consumption in HIV-associated AECOPD

ObjectiveTo delineate the distinct immunometabolic perturbations in HIV-associated acute exacerbation of chronic obstructive pulmonary disease (HIV-AECOPD) and to identify circulating biomarkers predictive of short-term prognosis.MethodsAn integrated proteomic and metabolomic discovery analysis was...

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Auteurs principaux:	Tao Qin, Wenlong Huang, Changwei Yang, Tianming Lu, Jun Wang, Jie Chen, Linli Chen, Tianyu Yan, Tingting Qian, Hao Yang, Linke Lu, Defa Huang, Minghong Zhao
Format:	Artigo
Langue:	Inglês
Publié:	Frontiers Media S.A. 2026-06-01
Collection:	Frontiers in Immunology
Sujets:	AECOPD biomarker CRP HIV immune dysregulation prognosis
Accès en ligne:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1855646/full
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