Nell-1 regulates fibrocartilage stem cells and alleviates temporomandibular joint osteoarthritis progression by inhibiting hedgehog pathway

Abstract Background Nel-like molecule-1 (Nell-1) could prevent the damage of cartilage in osteoarthritis (OA), including temporomandibular joint osteoarthritis (TMJOA), though, the definite mechanism of the process is unclear. Fibrocartilage stem cells (FCSCs) were discovered in the temporomandibula...

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Autori principali:	Shiyu Hu, Na Wu, Cunyi Wang, Wen Li, Jiejun Shi
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-01-01
Serie:	Journal of Orthopaedic Surgery and Research
Soggetti:	Temporomandibular disorders Osteoarthritis Cartilage Chondrogenic differentiation Nel-like molecule-1 Hedgehog
Accesso online:	https://doi.org/10.1186/s13018-025-06461-0
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