APOE genotype-dependent differences in human astrocytic energy metabolism

IntroductionThe main genetic risk factor for Alzheimer’s disease (AD) is the presence of the apolipoprotein E4 (APOE4) allele. While APOE4 increases the risk of developing AD, the APOE2 allele is protective and APOE3 is risk-neutral. In the brain, APOE is primarily expressed by astrocytes and plays...

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Κύριοι συγγραφείς:	Vanessa Budny, Chantal Bodenmann, Kathrin J. Zürcher, Maik Krüger, Sherida M. de Leeuw, Rebecca Z. Weber, Ruslan Rust, Luca Ravotto, Iván Ruminot, L. Felipe Barros, Bruno Weber, Christian Tackenberg
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Frontiers Media S.A. 2025-09-01
Σειρά:	Frontiers in Cellular Neuroscience
Θέματα:	apolipoprotein E (APOE) Alzheimer’s disease (AD) induced pluripotent stem cells (iPSCs) human astrocytes energy metabolism glycolysis
Διαθέσιμο Online:	https://www.frontiersin.org/articles/10.3389/fncel.2025.1603657/full
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