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Scoparone induces mitophagy and apoptosis via ROS accumulation in pancreatic cancer cells

Pancreatic cancer (PC) is one of the deadliest malignancies worldwide. In the present study, we demonstrated that a traditional Chinese medicine extract monomer, scoparone (Scop), significantly inhibited the growth of PC cells both in vitro and in vivo. Further studies revealed that Scop could induc...

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Hlavní autoři: Ningna Weng, Luping Lin, Tong Lin, Jinlu Liu, Kai Zhu, Sha Huang
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2026-01-01
Edice:Current Research in Toxicology
Témata:
Scoparone
Pancreatic cancer
Mitophagy
Apoptosis
ROS
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2666027X26000022
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