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Genomic and biological aspects of resistance to selective poly(ADP‐ribose) glycohydrolase inhibitor PDD00017273 in human colorectal cancer cells

Abstract Background Poly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP‐ribose) (PAR) metabolism and a potential anticancer target. Many drug candidates have been developed to inhibit its enzymatic activity. Additionally, PDD00017273 is an effective and selective inhibitor of PARG at...

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Principais autores: Kaede Tsuda, Chinatsu Kurasaka, Yoko Ogino, Akira Sato
Format: Artigo
Sprog:Inglês
Udgivet: Wiley 2023-02-01
Serier:Cancer Reports
Fag:
drug resistance
exome sequencing
PARG inhibitor
PDD00017273
poly(ADP‐ribose) glycohydrolase
Online adgang:https://doi.org/10.1002/cnr2.1709
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