Towards a cleaner CHO chassis: systematic knockout of host cell proteins for efficient biopharmaceutical manufacturing

Host cell proteins (HCPs) are major process‐related impurities in biopharmaceutical manufacturing, imposing metabolic burden on production hosts and complicating downstream purification, thereby impacting cost, product stability, and patient safety. Here, we engineered Chinese hamster ovary (CHO) ce...

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Autori principali:	Jannis Peter Marzluf, Jennifer Klein, Daniela Kirchmeier, Alexander Stärk, Daniel Ziegner, Markus Gehrung, Franziska Rauh, Merle Rattay, Christoph Zehe, Ann-Cathrin Leroux
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-01-01
Serie:	Frontiers in Bioengineering and Biotechnology
Soggetti:	biopharmaceuticals bioprocessing cell line development (CLD) Chinese hamster ovary cells (CHO) host cell protein (HCP) multiplex gene editing
Accesso online:	https://www.frontiersin.org/articles/10.3389/fbioe.2026.1750646/full
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