m6A-mediated stabilization of Bhlhe22 suppresses osteogenesis in osteoporosis by activating the PI3K-AKT-GSK3β signaling axis

Abstract Background Impaired osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) contributes to osteoporosis (OP) pathogenesis. While RNA modifications such as N6-methyladenosine (m6A) regulate stem cell differentiation, their role in OP remains unclear. Transcriptomic analysis...

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Hauptverfasser:	Qiaonan Ye, Qianke Tao, Xuemei Long, Fangzhi Lou, Jingxiang Li, Xiaobing Li, Dan Tan, Jingang Xiao
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-02-01
Schriftenreihe:	Stem Cell Research & Therapy
Schlagworte:	BMSCs Osteoporosis Bhlhe22 Osteogenesis PI3K-AKT-GSK3β axis N6-methyladenosine
Online-Zugang:	https://doi.org/10.1186/s13287-026-04935-4
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