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SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models

Survival motor neuron (SMN) is an essential and ubiquitously expressed protein that participates in several aspects of RNA metabolism. SMN deficiency causes a devastating motor neuron disease called spinal muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and...

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Principais autores: Julio Franco-Espin, Alaó Gatius, José Ángel Armengol, Saravanan Arumugam, Mehri Moradi, Michael Sendtner, Jordi Calderó, Lucia Tabares
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2022-10-01
Serier:Biomolecules
Fag:
spinal muscular atrophy
motor neuron degeneration
SMN granules
neuromuscular junction
<i>β-actin</i> mRNA
MAP1B
Online adgang:https://www.mdpi.com/2218-273X/12/10/1524
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