Supersaturated Lipid-Based Formulations to Enhance the Oral Bioavailability of Venetoclax

Increasing numbers of beyond Rule-of-Five drugs are emerging from discovery pipelines, generating a need for bio-enabling formulation approaches, such as lipid-based formulations (LBF), to ensure maximal in vivo exposure. However, many drug candidates display insufficient lipid solubility, leading t...

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Hlavní autoři:	Niklas J. Koehl, Laura J. Henze, Martin Kuentz, René Holm, Brendan T. Griffin
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2020-06-01
Edice:	Pharmaceutics
Témata:	lipid-based formulation venetoclax Super-SNEDDS supersaturation amorphous solubility landrace pigs
On-line přístup:	https://www.mdpi.com/1999-4923/12/6/564
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