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Human fetal kidney organoids model early human nephrogenesis and Notch-driven cell fate

Abstract Pluripotent stem cell (PSC)–derived kidney organoids are used to model human renal development and disease; however, accessible models of human fetal development to benchmark PSC-derived organoids remain underdeveloped. Here, we establish a chemically defined, serum-free protocol for prolon...

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Hlavní autoři: Michael Namestnikov, Osnat Cohen-Zontag, Dorit Omer, Yehudit Gnatek, Sanja Goldberg, Thomas Vincent, Swati Singh, Yair Shiber, Tal Rafaeli Yehudai, Hadas Volkov, Dani Folkman Genet, Achia Urbach, Sylvie Polak-Charcon, Igor Grinberg, Naomi Pode-Shakked, Boaz Weisz, Zvi Vaknin, Benjamin S Freedman, Benjamin Dekel
Médium: Artigo
Jazyk:Inglês
Vydáno: Springer Nature 2025-07-01
Edice:The EMBO Journal
Témata:
Human Fetal Kidney
Kidney Organoids
Nephrogenesis
Notch Pathway
Single-cell Transcriptomics
On-line přístup:https://doi.org/10.1038/s44318-025-00504-2
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