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Single-cell transcriptomics reveals mechanisms of Galt gene editing–induced liver injury involving HGF–VEGF–mediated intercellular signaling in mice

Galactosemia, a genetic disorder caused by mutations in the human GALT gene, often leads to multi-organ damage, with liver injury being particularly prominent. To elucidate the molecular mechanisms of Galt in liver injury, this study employed the CRISPR/Cas9 system to construct a Galt (c.847 + 1G &g...

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Principais autores: Zhihao Li, Ning Wang, Haolong Ruan, Qi Li, Xingling Zhang, Nian Liu, Yong Li, Lantao Gu, Pengpeng Yue, Honghao Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-01-01
coleção:Frontiers in Cell and Developmental Biology
Assuntos:
CRISPR/Cas9 system
galactosemia
Galt gene editing
liver injury
single-cell transcriptomics
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fcell.2025.1729321/full
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