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Maternal BCAA overnutrition programs persistent dysglycemia in lean adult offspring

Maternal nutrition exerts profound, lasting effects on offspring metabolic health, yet the impact of maternal overconsumption of key nutrients such as branched-chain amino acid (BCAAs) remains poorly understood. Here, we show that intake of a BCAA-enriched isocaloric, protein content-matched diet th...

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Principais autores: Joyce Tzeng, Ismael Ferrer, Damaris N. Lorenzo
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-03-01
Serier:Molecular Metabolism
Fag:
Maternal nutrition
BCAA
Developmental programming
Glucose homeostasis
PGC-1α signaling
Metabolic flexibility
Online adgang:http://www.sciencedirect.com/science/article/pii/S2212877826000153
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