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Inhibition of the PLK1‐Coupled Cell Cycle Machinery Overcomes Resistance to Oxaliplatin in Colorectal Cancer

Abstract Dysregulation of the cell cycle machinery leads to genomic instability and is a hallmark of cancer associated with chemoresistance and poor prognosis in colorectal cancer (CRC). Identifying and targeting aberrant cell cycle machinery is expected to improve current therapies for CRC patients...

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Автори: Zhaoliang Yu, Peng Deng, Yufeng Chen, Shini Liu, Jinghong Chen, Zihuan Yang, Jianfeng Chen, Xinjuan Fan, Peili Wang, Zerong Cai, Yali Wang, Peishan Hu, Dezheng Lin, Rong Xiao, Yifeng Zou, Yan Huang, Qiang Yu, Ping Lan, Jing Tan, Xiaojian Wu
Формат: Artigo
Мова:Inglês
Опубліковано: Wiley 2021-12-01
Серія:Advanced Science
Предмети:
cell division cycle 7
colorectal cancer
MYC
oxaliplatin
polo‐like kinase 1
Онлайн доступ:https://doi.org/10.1002/advs.202100759
Теги: Додати тег
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