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Synthesis and G-Quadruplex-Binding Properties of Defined Acridine Oligomers

The synthesis of oligomers containing two or three acridine units linked through 2-aminoethylglycine using solid-phase methodology is described. Subsequent studies on cell viability showed that these compounds are not cytotoxic. Binding to several DNA structures was studied by competitive dialysis,...

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Autores principales: Rubén Ferreira, Anna Aviñó, Ricardo Pérez-Tomás, Raimundo Gargallo, Ramon Eritja
Formato: Artigo
Lenguaje:Inglês
Publicado: Wiley 2010-01-01
Colección:Journal of Nucleic Acids
Acceso en línea:http://dx.doi.org/10.4061/2010/489060
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