Design, Synthesis, Molecular Modeling, and Biological Evaluation of Novel Thiouracil Derivatives as Potential Antithyroid Agents
Hyperthyroidism is the result of uncontrolled overproduction of the thyroid hormones. One of the mostly used antithyroid agents is 6-<i>n-</i>propyl-2-thiouracil (PTU). The previously solved X-ray crystal structure of the PTU bound to mammalian lactoperoxidase (LPO) reveals that the LPO-PTU binding...
Sparad:
| Huvudupphov: | , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
MDPI AG
2018-11-01
|
| Serie: | Molecules |
| Ämnen: | |
| Länkar: | https://www.mdpi.com/1420-3049/23/11/2913 |
| Taggar: |
Inga taggar, Lägg till första taggen!
|