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Mitochondrial targeting by dichloroacetate improves outcome following hemorrhagic shock

Abstract Hemorrhagic shock is a leading cause of death in people under the age of 45 and accounts for almost half of trauma-related deaths. In order to develop a treatment strategy based on potentiating mitochondrial function, we investigated the effect of the orphan drug dichloroacetate (DCA) on su...

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Príomhchruthaitheoirí: Kumar Subramani, Sumin Lu, Marie Warren, Xiaogang Chu, Haroldo A. Toque, R. William Caldwell, Michael P. Diamond, Raghavan Raju
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2017-06-01
Sraith:Scientific Reports
Rochtain ar líne:https://doi.org/10.1038/s41598-017-02495-5
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