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A monoclonal antibody-GDNF fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys.

Glial cell line derived neurotrophic factor (GDNF) is a neurotrophic factor that has neuroprotective effects in animal models of Parkinson's disease (PD) and has been proposed as a PD therapy. GDNF does not cross the blood brain barrier (BBB), and requires direct intracerebral delivery to be effecti...

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Main Authors: Sachiko Ohshima-Hosoyama, Heather A Simmons, Nichole Goecks, Valerie Joers, Christine R Swanson, Viktoriya Bondarenko, Rebecca Velotta, Kevin Brunner, Laura D Wood, Ralph H Hruban, Marina E Emborg
Format: Artigo
Language:Inglês
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3380056?pdf=render
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