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Mycophenolic acid, the active form of mycophenolate mofetil, interferes with IRF7 nuclear translocation and type I IFN production by plasmacytoid dendritic cells

Abstract Background Both humoral and cellular immune mechanisms are involved in the onset and progression of autoimmune responses in systemic lupus erythematosus (SLE). Plasmacytoid dendritic cells (pDCs) play a central role in the pathogenesis of SLE via the dysregulation of type I interferon (IFN)...

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Wedi'i Gadw mewn:
Prif Awduron: Minoru Shigesaka, Tomoki Ito, Muneo Inaba, Kai Imai, Hideki Yamanaka, Yoshiko Azuma, Akihiro Tanaka, Hideki Amuro, Tohru Nishizawa, Yonsu Son, Atsushi Satake, Yoshio Ozaki, Shosaku Nomura
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: BMC 2020-11-01
Cyfres:Arthritis Research & Therapy
Pynciau:
SLE
Plasmacytoid DCs
Myeloid DCs
Type I IFN
MPA
IRF7
Mynediad Ar-lein:http://link.springer.com/article/10.1186/s13075-020-02356-z
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