Neutrophil-specific targeting of STAT3 impairs tumor progression via the expansion of cytotoxic CD8+ T cells

Abstract Neutrophils have emerged as key players in tumor progression and are often associated with poor prognosis. Despite ongoing efforts to target neutrophil functions in cancer, therapeutic success has been limited. In this study, we addressed the possibility of blocking STAT3 signaling in neutr...

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Autors principals:	Irem Ozel, Guanyu Sha, Agnieszka Będzińska, Ekaterina Pylaeva, Yuliia Naumova, Ilona Thiel, Joanna Antczak, Anthony Squire, Matthias Gunzer, Gennadiy Zelinskyy, Cornelius Kürten, Stephan Lang, Carlos Silvestre-Roig, Marcin Kortylewski, Zvi Granot, Jadwiga Jablonska
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Publishing Group 2025-08-01
Col·lecció:	Signal Transduction and Targeted Therapy
Accés en línia:	https://doi.org/10.1038/s41392-025-02363-z
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