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The tumor suppressor BRCA1-BARD1 complex localizes to the synaptonemal complex and regulates recombination under meiotic dysfunction in Caenorhabditis elegans.

Breast cancer susceptibility gene 1 (BRCA1) and binding partner BRCA1-associated RING domain protein 1 (BARD1) form an essential E3 ubiquitin ligase important for DNA damage repair and homologous recombination. The Caenorhabditis elegans orthologs, BRC-1 and BRD-1, also function in DNA damage repair...

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Principais autores: Qianyan Li, Takamune T Saito, Marina Martinez-Garcia, Alison J Deshong, Saravanapriah Nadarajan, Katherine S Lawrence, Paula M Checchi, Monica P Colaiacovo, JoAnne Engebrecht
פורמט: Artigo
שפה:Inglês
יצא לאור: Public Library of Science (PLoS) 2018-11-01
סדרה:PLoS Genetics
גישה מקוונת:http://europepmc.org/articles/PMC6211623?pdf=render
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