Ultra-broad hybrid capture-based targeted next-generation sequencing for sensitive plasma pathogen cfDNA detection in bloodstream infections

Abstract Background The limited genomic targeting range of current targeted next-generation sequencing (tNGS) workflows results in limited detection of pathogen-derived cell-free DNA (cfDNA), making it challenging to apply this approach to bloodstream infections (BSIs). Here, we developed an ultra-b...

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Detalhes bibliográficos

Principais autores:	Muyun Wei, Xiangzhao Ai, Dejian Gu, Shengyang Zhang, Ke Xu, Shuangshuang Li, Shaowei Mao, Min Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-10-01
coleção:	Journal of Translational Medicine
Assuntos:	Ultra-broad hybrid capture-based targeted next-generation sequencing (tNGS) CfDNA Bloodstream infections (BSI) Immunocompromised patients Metagenomic next-generation sequencing (mNGS)
Acesso em linha:	https://doi.org/10.1186/s12967-025-07258-9
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