The Klotho protein supports redox balance and metabolic functions of cardiomyocytes during ischemia/reperfusion injury

BACKGROUND: Acute heart ischemia followed by reperfusion leads to overproduction of reactive oxygen/ /nitrogen species (ROS/RNS), disrupted expression of nitric oxide synthase (NOS) and unbalanced glucose metabolism. Klotho is a membrane-bound or soluble protein that exerts protective activity in ma...

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Библиографические подробности
Главные авторы: Agnieszka Olejnik, Marta Banaszkiewicz, Anna Krzywonos-Zawadzka, Iwona Bil-Lula
Формат: Artigo
Язык:Inglês
Опубликовано: Via Medica 2022-09-01
Серии:Cardiology Journal
Предметы:
Klotho protein
cardioprotection
heart
ischemia/reperfusion injury
oxidative stress
nitrosative stress
Online-ссылка:https://journals.viamedica.pl/cardiology_journal/article/view/76177
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