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Blood-brain barrier water exchange in relation to amyloid, cognition and cerebrovascular burden

Blood-brain barrier (BBB) water exchange may serve as a sensitive early biomarker for Alzheimer’s disease and age-related cognitive decline. This study applied a non-invasive multi-echo arterial spin labeling (ASL) technique to measure BBB water exchange time (Tex), cerebral blood flow (CBF), and ar...

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Autori principali: Beatriz E. Padrela, Sandra Tecelão, Bjørn-Eivind Kirsebom, Oliver Geier, Mario Tranfa, Federico Masserini, Markus H. Sneve, Maksim Slivka, Emilie Sogn Falch, Lene Pålhaugen, Amnah Mahroo, Klaus Eickel, David L. Thomas, Matthias Günther, Per Selnes, Atle Bjørnerud, Kristine B. Walhovd, Anders M. Fjell, Frederik Barkhof, Jan Petr, Tormod Fladby, Henk J.M.M. Mutsaerts
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2026-01-01
Serie:NeuroImage: Clinical
Soggetti:
Blood-brain barrier water exchange
Arterial spin labeling
Cerebral blood flow
Amyloid
Cognition
Cerebrovascular damage
Accesso online:http://www.sciencedirect.com/science/article/pii/S2213158225001998
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