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Synthesis and Anticancer Cytotoxicity of Azaaurones Overcoming Multidrug Resistance

The resistance of tumors against anticancer drugs is a major impediment for chemotherapy. Tumors often develop multidrug resistance as a result of the cellular efflux of chemotherapeutic agents by ABC transporters such as P-glycoprotein (ABCB1/P-gp), Multidrug Resistance Protein 1 (ABCC1/MRP1), or B...

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Principais autores: Szilárd Tóth, Áron Szepesi, Viet-Khoa Tran-Nguyen, Balázs Sarkadi, Katalin Német, Pierre Falson, Attilio Di Pietro, Gergely Szakács, Ahcène Boumendjel
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-02-01
Serier:Molecules
Fag:
aurone
azaaurone
multidrug resistance
p-gp
overexpression
anticancer
cytotoxicity
Online adgang:https://www.mdpi.com/1420-3049/25/3/764
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