Loss of Perp in T Cells Promotes Resistance to Apoptosis of T Helper 17 Cells and Exacerbates the Development of Experimental Autoimmune Encephalomyelitis in Mice

T helper 17 (Th17) cells are crucial for the pathogenesis of multiple sclerosis (MS) in humans and experimental autoimmune encephalomyelitis (EAE) in animals. High frequency of Th17 cells and low sensitivity to activation-induced cell death (AICD) are detected in MS patients. However, the mechanisms...

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書誌詳細

主要な著者:	Yan Zhou, Xiao Leng, Yan He, Yan Li, Yuan Liu, Yang Liu, Qiang Zou, Guixiu Shi, Yantang Wang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2018-04-01
シリーズ:	Frontiers in Immunology
主題:	Perp T helper 17 cell activation-induced cell death experimental autoimmune encephalomyelitis/multiple sclerosis caspase activation
オンライン･アクセス:	http://journal.frontiersin.org/article/10.3389/fimmu.2018.00842/full
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