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Functional microRNA targetome undergoes degeneration-induced shift in the retina

Abstract Background MicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases including age-related macular degeneration (AMD), acting as post-transcriptional gene suppressors through their association with argonaute 2 (AGO2) - a key member of the RNA Induced...

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Principais autores: Joshua A. Chu-Tan, Adrian V. Cioanca, Zhi-Ping Feng, Yvette Wooff, Ulrike Schumann, Riemke Aggio-Bruce, Hardip Patel, Matt Rutar, Katherine Hannan, Konstantin Panov, Jan Provis, Riccardo Natoli
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-08-01
Serier:Molecular Neurodegeneration
Fag:
Retina
microRNA
mRNA
Retinal degeneration
Argonaute
HITS-CLIP
Online adgang:https://doi.org/10.1186/s13024-021-00478-9
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