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TGF-β1 Inhibition of ACE2 Mediated by miRNA Uncovers Novel Mechanism of SARS-CoV-2 Pathogenesis

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, utilizes receptor binding domain (RBD) of spike glycoprotein to interact with angiotensin (Ang)-converting enzyme 2 (ACE2). Altering ACE2 levels may affect entry of SARS-CoV-2 and recovery from COVID-19. Decr...

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Principais autores: Ewelina D. Hejenkowska, Nilay Mitash, Joshua E. Donovan, Anvita Chandra, Carol Bertrand, Chiara De Santi, Catherine M. Greene, Fangping Mu, Agnieszka Swiatecka-Urban
Formato: Artigo
Idioma:Inglês
Publicado em: Karger Publishers 2023-08-01
coleção:Journal of Innate Immunity
Assuntos:
severe acute respiratory syndrome coronavirus 2
angiotensin-converting enzyme 2
cystic fibrosis
tgf-β1
mirna
Acesso em linha:https://beta.karger.com/Article/FullText/533606
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