Type I interferon suppresses tumor growth through activating the STAT3-granzyme B pathway in tumor-infiltrating cytotoxic T lymphocytes

Abstract Background Type I interferons (IFN-I) have recently emerged as key regulators of tumor response to chemotherapy and immunotherapy. However, IFN-I function in cytotoxic T lymphocytes (CTLs) in the tumor microenvironment is largely unknown. Methods Tumor tissues and CTLs of human colorectal c...

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Detalhes bibliográficos

Principais autores:	Chunwan Lu, John D. Klement, Mohammed L. Ibrahim, Wei Xiao, Priscilla S. Redd, Asha Nayak-Kapoor, Gang Zhou, Kebin Liu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMJ Publishing Group 2019-06-01
coleção:	Journal for ImmunoTherapy of Cancer
Assuntos:	Type I interferon CTLs STAT3 Granzyme B Colon Cancer
Acesso em linha:	http://link.springer.com/article/10.1186/s40425-019-0635-8
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