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TIE2-positive cells in the nucleus pulposus with a purpose: the who, what and why

Abstract Once thought to be solely involved in vasculogenesis, tyrosine kinase with immunoglobulin-like and EGF-like domains 2 (TIE2) has emerged as a crucial marker of progenitor-like cells in the avascular nucleus pulposus (NP), a tissue with notoriously limited regenerative capacity. Recent evide...

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Principais autores: Jordy Schol, Luca Ambrosio, Clara Ruiz-Fernandez, Leon Schlagenhof, Chantal Voskamp, Lisanne T. Laagland, Erika Matsushita, Hazuki Soma, Takayuki Warita, Gianluca Vadalà, Marianna A. Tryfonidou, Benjamin Gantenbein, Daisuke Sakai
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-03-01
Serier:Journal of Biomedical Science
Fag:
Intervertebral disc
Progenitor cells
Notochord
Angiopoietins
Extracellular matrix
Cellular therapy
Online adgang:https://doi.org/10.1186/s12929-026-01220-7
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