Conformationally locked 7-aryl tetrahydroisoquinolines as dual acetylcholinesterase inhibitors and antioxidants: role of intramolecular hydrogen bonding and aryl electronics

BackgroundAlzheimer’s disease (AD) is a multifactorial neurodegenerative disorder in which cholinergic dysfunction and oxidative stress act as synergistic contributors to cognitive decline and neuronal damage. Multitarget-directed ligands (MTDLs) capable of modulating both acetylcholinesterase (AChE...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Valentina Ríos, Camila Linares-Pipón, Cristián Maulén, Alejandro Castro-Álvarez, Ben Bradshaw, Javier Romero-Parra, Mauricio A. Cuellar, Maximiliano Martínez-Cifuentes, Claudio Parra
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-04-01
Serie:	Frontiers in Pharmacology
Soggetti:	antioxidants density functional theory molecular docking multitarget-directed ligands structure–activity relationships tetrahydroisoquinolin
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1797738/full
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!