The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer

Abstract Background Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but its potential impact on EC remains unclear. We therefore aimed to eluci...

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Detalhes bibliográficos

Principais autores:	Yingxin Pang, Gaigai Bai, Jing Zhao, Xuan Wei, Rui Li, Jie Li, Shunxue Hu, Lu Peng, Peishu Liu, Hongluan Mao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2022-07-01
coleção:	Journal of Translational Medicine
Assuntos:	Endometrial cancer BRD4 JQ1 Cell apoptosis Cell cycle arrest c-Myc
Acesso em linha:	https://doi.org/10.1186/s12967-022-03545-x
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