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Identification and heterologous expression of the globomycin biosynthetic gene cluster

Globomycin is a cyclic lipodepsipeptide originally isolated from several Streptomyces species which displays strong and selective antibacterial activity against Gram-negative pathogens. Its mode of action is based on the competitive inhibition of the lipoprotein signal peptidase II (LspA), which is...

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Main Authors: Daniel Oves-Costales, Tetiana Gren, Eva Baggesgaard Sterndorff, Jesús Martín, Francisco Javier Ortiz-López, Tue S. Jørgensen, Xinglin Jiang, Fernando Román-Hurtado, Fernando Reyes, Olga Genilloud, Tilmann Weber
Format: Artigo
Language:Inglês
Published: KeAi Communications Co., Ltd. 2023-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Globomycin
Signal peptidase II
Cyclic lipodepsipeptide
Genome mining
CRISPR-cBEST
Heterologous expression
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X23000066
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