Cisplatin-induced increase in heregulin 1 and its attenuation by the monoclonal ErbB3 antibody seribantumab in bladder cancer

Abstract Cisplatin-based combination chemotherapy is the foundation for treatment of advanced bladder cancer (BlCa), but many patients develop chemoresistance mediated by increased Akt and ERK phosphorylation. However, the mechanism by which cisplatin induces this increase has not been elucidated. A...

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Bibliografiske detaljer

Principais autores:	Thomas M. Steele, Maria Malvina Tsamouri, Salma Siddiqui, Christopher A. Lucchesi, Demitria Vasilatis, Benjamin A. Mooso, Blythe P. Durbin-Johnson, Ai-Hong Ma, Nazila Hejazi, Mamta Parikh, Maria Mudryj, Chong-xian Pan, Paramita M. Ghosh
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2023-06-01
Serier:	Scientific Reports
Online adgang:	https://doi.org/10.1038/s41598-023-36774-1
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