An iPSC-based in vitro model recapitulates human thymic epithelial development and multi-lineage specification

Abstract Thymic epithelial cells (TEC) are crucial in supporting T cell development, but their high heterogeneity and difficulty of isolation pose obstacles to their study in humans. Particularly, how diverse TEC lineages arise from a common progenitor remains poorly understood. To address this, her...

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Detalhes bibliográficos

Principais autores:	Yann Pretemer, Yuxian Gao, Kaho Kanai, Takuya Yamamoto, Kohei Kometani, Manami Ozaki, Karin Nishigishi, Tadashi Ikeda, Huaigeng Xu, Akitsu Hotta, Yoko Hamazaki
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-08-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-025-62523-1
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