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Analysis of MHC class II-bound CyHV-2 peptides in Carassius gibelio using mass spectrometry

ABSTRACT Class II major histocompatibility complexes (MHC-II) are a highly polymorphic and multigenic family of molecules that present exogenous peptides to CD4+ helper T cells, thereby activating the host adaptive immune system. In this study, we systematically analyzed the genomic distribution and...

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Main Authors: Chen Xu, Fangxing Yu, Jiajia Ye, Mingyang Xue, Zhenyu Huang, Nan Jiang, Yan Meng, Yuding Fan, Weiguang Kong, Ya Zheng, Yong Zhou
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2026-02-01
Series:Journal of Virology
Subjects:
teleost
polymorphism
immunopeptidome
MHC-II peptides
Cyprinid herpesvirus 2
Online Access:https://journals.asm.org/doi/10.1128/jvi.01870-25
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