Successful development of squamous cell carcinoma and hyperplasia in RGEN-mediated p27 KO mice after the treatment of DMBA and TPA

Abstract To evaluate the carcinogenicity of p27 knockout (KO) mice with RNA-guided endonuclease (RGENs)-mediated p27 mutant exon I gene (IΔ), alterations in the carcinogenic phenotypes including tumor spectrum, tumor suppressor proteins, apoptotic proteins and cell cycle regulators were observed in...

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Autors principals:	Jun Young Choi, Woo Bin Yun, Ji Eun Kim, Mi Rim Lee, Jin Ju Park, Bo Ram Song, Hye Ryeong Kim, Ji Won Park, Mi Ju Kang, Byeong Cheol Kang, Han-Woong Lee, Dae Youn Hwang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2018-12-01
Col·lecció:	Laboratory Animal Research
Matèries:	p27 tumorigenesis DMBA TPA carcinoma hyperplasia
Accés en línia:	http://link.springer.com/article/10.5625/lar.2018.34.3.118
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