Molecular signatures of alveolar type II cell differentiation in acute respiratory distress syndrome

BackgroundAcute respiratory distress syndrome (ARDS) is a life-threatening lung condition with high morbidity and mortality.MethodsWe analyzed publicly available single-cell transcriptomic and microarray datasets from murine ARDS models to characterize AT2 cell differentiation trajectories following...

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Bibliographic Details
Main Authors: Yu Zhang, Yazhe Wang, Chunsheng Wen, Haixu Wang, Liping Wang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2025-09-01
Series:Frontiers in Medicine
Subjects:
acute respiratory distress syndrome
type II alveolar epithelial cells
cell differentiation
trajectory analysis
marker genes
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2025.1649108/full
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